The REGICOR mission is to contribute to the available knowledge about the magnitude and causes of cardiovascular diseases. Researchers study the influence of molecular, cellular, and environmental mechanisms, with an emphasis on nutrition, physical activity, and obesity; the development of coronary disease; and the best prevention strategies at population scale. The final objective is to contribute to a significant reduction in the burden of these diseases. REGICOR also has a mission to prepare new researchers in this knowledge area.


The disease burden of ischemic heart diseases is reduced throughout western society by the collaborative and multidisciplinary efforts of an expert research community. Widespread knowledge of the protective factors discovered in South Europe and of the molecular end cellular mechanisms of disease contributes to coordinated efforts that continuously improve the accurate estimation of cardiovascular risk in any population and the implementation of optimal strategies of primary prevention.

  •  In Western society, the effects of dietary excesses and imbalance and a lack of exercise result in obesity, metabolic disorders, and cardiovascular diseases.
  • South Europe has lower rates of ischemic heart disease mortality and incidence than those of North, Central, East or West Europe, despite an elevated prevalence of cardiovascular risk factors. This situation suggests the existence of protective genetic or environmental factors that have been at work for decades, especially in France and Spain.
  • Accurate estimation of cardiovascular risk in any population is a priority requirement for the development of optimal strategies of primary prevention. Therefore, we must devise strategies to disseminate these strategies and perfect their predictive capacity.
  • Many molecular and cellular mechanisms are involved in this process, including population genetics, HDL functions, methylation, epigenetics, and gene expression. In turn, many of these mechanisms and their expression as subclinical diseases are measurable biomarkers that can contribute to cardiovascular risk prediction.
  • Only a collaborative and multidisciplinary approach will guarantee research success in this field.