The estimation of myocardial infarction incidence, mortality and survival rates requires access to population registers with a standardized methodology and the following characteristics: First, the study population must be clearly defined and stable over time, making it possible to compare epidemiologic indicators. Second, the study definition of the disease must be standardized, valid, reliable and reproducible and permit comparison of the results with other studies in different populations. Finally, all myocardial infarctions in all hospitals in the study area must be monitored, as well as the healthcare transport involved, and cause of death must be validated by consulting the official death records.

The REGICOR population register began in 1990, meeting all of these conditions. The register contains sociodemographic and clinical data on all cases of myocardial infarction that occurred through 2009 among approximately 600,000 residents of the 6 counties of the province of Girona (L’Alt Empordà, El Baix Empordà, La Garrotxa, El Gironès, El Pla de l’Estany and La Selva). The data sources during these 20 years were all of the hospitals and clinical centres in the study area, ambulance records, and the official death register, with the goal of compiling an exhaustive register.

The study of prognosis and treatment effectiveness requires hospital registers that contain information about all individuals with the same diagnosis attending a particular healthcase centre. The REGICOR hospital register created for this purpose in 1978 includes all patients diagnosed with a first myocardial infarction from that year through 2009 at Josep Trueta University Hospital in Girona. More than 30 years of REGICOR data collection has also permitted an analysis of changes in patient management and the treatment of patients with myocardial infarction.

Pocock S, Calvo G, Marrugat J, Prasad K, Tavazzi L, Wallentin L, Zannad F, Alonso Garcia A

International differences in treatment effect: do they really exist and why?

Eur. Heart J. 2013 Jun; 34 (24): 1846-52, PMID: 23475529


Grau M, Sala C, Sala J, Masiá R, Vila J, Subirana I, Ramos R, Elosua R, Brugada R, Marrugat J

Sex-related differences in prognosis after myocardial infarction: changes from 1978 to 2007.

Eur. J. Epidemiol. 2012 Nov; 27 (11): 847-55, PMID: 22777715


Kaski JC, Fernandez-Berges DJ, Consuegra-Sanchez L, Fernández JM, Garcia-Moll X, Mostaza JM, Cebada RT, Juanatey JR, Martínez GG, Marrugat J

A comparative study of biomarkers for risk prediction in acute coronary syndrome-Results of the SIESTA (Systemic Inflammation Evaluation in non-ST-elevation Acute coronary syndrome) study.

Atherosclerosis 2010 Oct; 212 (2): 636-43, PMID: 20619836


Bosch X, Marrugat J, Sanchis J

Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes.

Cochrane Database Syst Rev 2010 (9): CD002130, PMID: 20824831


Ferreira-González I, Marsal JR, Mitjavila F, Parada A, Ribera A, Cascant P, Soriano N, Sánchez PL, Arós F, Heras M, Bueno H, Marrugat J, Cuñat J, Civeira E, Permanyer-Miralda G

Patient registries of acute coronary syndrome: assessing or biasing the clinical real world data?

Circ Cardiovasc Qual Outcomes 2009 Nov; 2 (6): 540-7, PMID: 20031891


Muñoz MA, Subirana I, Ramos R, Franzi A, Vila J, Marrugat J

[Efficacy of an intensive prevention programme of coronary heart disease: 5 year follow-up outcomes].

Med Clin (Barc) 2008 Apr; 130 (14): 521-5, PMID: 18457617


Munoz MA, Vila J, Cabañero M, Rebato C, Subirana I, Sala J, Marrugat J

Efficacy of an intensive prevention program in coronary patients in primary care, a randomised clinical trial.

Int. J. Cardiol. 2007 Jun; 118 (3): 312-20, PMID: 17261336


Lanki T, Pekkanen J, Aalto P, Elosua R, Berglind N, D'Ippoliti D, Kulmala M, Nyberg F, Peters A, Picciotto S, Salomaa V, Sunyer J, Tiittanen P, von Klot S, Forastiere F

Associations of traffic related air pollutants with hospitalisation for first acute myocardial infarction: the HEAPSS study.

Occup Environ Med 2006 Dec; 63 (12): 844-51, PMID: 16912091


Munoz MA, Rohlfs I, Masuet S, Rebato C, Cabañero M, Marrugat J

Analysis of inequalities in secondary prevention of coronary heart disease in a universal coverage health care system.

Eur J Public Health 2006 Aug; 16 (4): 361-7, PMID: 16230314


Munoz MA, Manresa JM, Espinasa J, Marrugat J

Association of time elapsed since the last coronary event with health services utilization.

Eur. J. Epidemiol. 2005 20 (3): 221-7, PMID: 15921039


Marrugat J, Sala J, Manresa JM, Gil M, Elosua R, Pérez G, Albert X, Pena A, Masiá R

Acute myocardial infarction population incidence and in-hospital management factors associated to 28-day case-fatality in the 65 year and older.

Eur. J. Epidemiol. 2004 19 (3): 231-7, PMID: 15117116


Muñoz MA, Marrugat J

[Secondary prevention of coronary heart disease is less agressive in patients over 64 years].

Rev Esp Cardiol 2003 Jun; 56 (6): 586-93, PMID: 12783734


Rohlfs I, Elosua R, Masiá R, Sala J, Marrugat J

[Trends in the proportion of patients younger than 75 years with acute myocardial infarction and Killip class III and IV. variables associated with occurence and case-fatality: 1978-1997].

Rev Esp Cardiol 2002 Nov; 55 (11): 1117-23, PMID: 12423567


Sala J, Masiá R, González de Molina FJ, Fernández-Real JM, Gil M, Bosch D, Ricart W, Sentí M, Marrugat J

Short-term mortality of myocardial infarction patients with diabetes or hyperglycaemia during admission.

J Epidemiol Community Health 2002 Sep; 56 (9): 707-12, PMID: 12177090


Marrugat J, Gil M, Masiá R, Sala J, Elosua R, Antó JM

Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction.

J Epidemiol Community Health 2001 Jul; 55 (7): 487-93, PMID: 11413178


Bosch X, Marrugat J

Platelet glycoprotein IIb/IIIa blockers for percutaneous coronary revascularization, and unstable angina and non-ST-segment elevation myocardial infarction.

Cochrane Database Syst Rev 2001 (4): CD002130, PMID: 11687143


Marrugat J, Ferrières J, Masiá R, Ruidavets J, Sala J

Differences in use of coronary angiography and outcome of myocardial infarction in Toulouse (France) and Gerona (Spain). The MONICA-Toulouse and REGICOR investigators.

Eur. Heart J. 2000 May; 21 (9): 740-6, PMID: 10739729


Marrugat J, Gil M, Sala J

Sex differences in survival rates after acute myocardial infarction.

J Cardiovasc Risk 1999 Apr; 6 (2): 89-97, PMID: 10353068


Gil M, Marrugat J, Sala J, Masiá R, Elosua R, Albert X, Pena A, Vila J, Pavesi M, Pérez G

Relationship of therapeutic improvements and 28-day case fatality in patients hospitalized with acute myocardial infarction between 1978 and 1993 in the REGICOR study, Gerona, Spain. The REGICOR Investigators.

Circulation 1999 Apr; 99 (13): 1767-73, PMID: 10190889


Sala J, Marrugat J, Masiá R, Porta M

Improvement in survival after myocardial infarction between 1978-85 and 1986-88 in the REGICOR study. (Registre GIroní del COR) registry.

Eur. Heart J. 1995 Jun; 16 (6): 779-84, PMID: 7588921


Marrugat J, Antó JM, Sala J, Masiá R

Influence of gender in acute and long-term cardiac mortality after a first myocardial infarction. REGICOR Investigators.

J Clin Epidemiol 1994 Feb; 47 (2): 111-8, PMID: 8113820


Hallstrom AP, Marrugat J, Pérez G, Masiá R, Sala J, Maynard C, Schaffer S, Weaver WD

Characteristics of Myocardial Infarction Episodes in Two Distant Communities: From the REGICOR Registry in Girona, Spain and the MITI Registry in Greater Seattle, USA.

J. Thromb. Thrombolysis 1994 1 (1): 85-93, PMID: 10603517


Arós Borau F, Marrugat de la Iglesia J, Bayón Fernández J, Mayordomo López JA

[Epidemiological data and the physiopathology of acute myocardial infarct].

Rev Esp Cardiol 1994 47 Suppl 1 3-8, PMID: 7991929


Marrugat J, Sala J, Masiá R

[The role of sex in the survival in myocardial infarction. Researchers of the REGICOR study].

Med Clin (Barc) 1994 Jun; 103 (3): 119, PMID: 8065220


Marrugat J, Sala J, Masiá R

[Evaluation of the role of the female gender in the prognosis following acute myocardial infarction].

Rev Esp Cardiol 1994 Jun; 47 (6): 414-6, PMID: 8066315


Marrugat J, Sala J, Ribalta A, Sanz F

[Ten-year survival of a cohort of 736 patients with a first myocardial infarction. Sex-related differences?].

Rev Esp Cardiol 1991 May; 44 (5): 297-305, PMID: 1852958