Lluís-Ganella C, Lucas G, Subirana I, Sentí M, Jimenez-Conde J, Marrugat J, Tomás M, Elosua R,

Additive effect of multiple genetic variants on the risk of coronary artery disease.

Rev Esp Cardiol 2010 Aug; 63 (8): 925-33, PMID: 20738937

Coronary artery disease (CAD) has a substantial genetic component and, in recent years, a number of genetic variants associated with the disease have been identified. The objective of this study was to evaluate the magnitude of the association between a genetic risk score, which is based on the accumulated number of risk alleles in all genetic variants of interest, and the presence of CAD.

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