Lluís-Ganella C, Subirana I, Lucas G, Tomás M, Muñoz D, Sentí M, Salas E, Sala J, Ramos R, Ordovás JM, Marrugat J, Elosua R,

Assessment of the value of a genetic risk score in improving the estimation of coronary risk.

Atherosclerosis 2012 Jun; 222 (2): 456-63, PMID: 22521901

The American Heart Association has established criteria for the evaluation of novel markers of cardiovascular risk. In accordance with these criteria, we assessed the association between a multi-locus genetic risk score (GRS) and incident coronary heart disease (CHD), and evaluated whether this GRS improves the predictive capacity of the Framingham risk function.

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