Domingues-Montanari S, Subirana I, Tomás M, Marrugat J, Sentí M,

Association between ESR2 genetic variants and risk of myocardial infarction.

Clin. Chem. 2008 Jul; 54 (7): 1183-9, PMID: 18487282

Environmental and genetic factors contribute to the development of complex diseases such as myocardial infarction (MI), the leading cause of death in men and women. Women develop MI approximately 10 years later than men, a difference that could be explained by the genes coding for the estrogen receptors. Single nucleotide polymorphisms (SNPs) in the ESR2 gene may affect susceptibility for MI in a sex-dependent manner.

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