Tomás M, Vázquez E, Fernández-Fernández JM, Subirana I, Plata C, Heras M, Vila J, Marrugat J, Valverde MA, Sentí M,

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction.

J. Hypertens. 2008 Nov; 26 (11): 2147-53, PMID: 18854754

The large conductance Ca2+ -dependent potassium channel plays a critical role in the control of vascular tone, coupling local increases in intracellular Ca2+ to membrane hyperpolarization and vascular relaxation. It also impacts blood pressure by modulating the renin-angiotensin-aldosterone system. Previous studies have shown that a polymorphism in the beta1 regulatory subunit of the Ca2+ -dependent potassium channel modulates the risk of diastolic hypertension in humans.

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